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Fluorescently labeled RXI-231 was applied to the surface of full thickness porcine explant skin. A DermaPen® fractional microneedle device was passed over the surface of the skin to create microchannels (1.0 mm depth) through which the compounds enter the skin. Following 24 hours on a Franz cell system, dermal penetration is detected by fluorescence microscopy (20x magnification). Dermal penetration to a depth of 400 nm was achieved with good cellular uptake observed.
