Table 2:

Summary of studies on TRT effect on COPD

Authors, Year	Country	Study Design	Number of Participants	Intervention	Outcome of Interest	Study Findings
Baillargeon et al (2018)	USA	Retrospective	703	Comparison of middle-aged (40–63 years old) and older men (>= 66 years) before and after TRT against non-users Duration: 24 months	Pre- vs. post TRT respiratory hospitalization rates in TRT users vs. TRT nonusers	TRT significantly reduced respiratory hospitalization in the middle-aged cohort following therapy as compared to prior but did not significantly reduced hospitalization in the older cohort. However, overall TRT users experienced a 4–9% decrease in respiratory hospitalizations as compared to non-users.
Atlantis et al (2013)	New South Wales	Review/meta-analysis	287	Comparison of TRT users vs. TRT nonusers	Peak muscle strength, peak cardiorespiratory fitness outcomes (peak oxygen uptake VO2 and workload), health-related quality of life (HRQoL)	Testosterone therapy is associated with improved exercise capacity outcomes, namely peak muscle strength and peak workload.
Daga et al (2014)	India	Prospective	32	25 mg of nandrolone decanoate or placebo intramuscularly in the gluteal muscle weekly Duration: 6 weeks	Anthropometric and spirometric measurements, peak respiratory flow rate, partial pressure of O2 in arterial blood, 6-minute walk test (6MWT), hand grip test, and HRQL index scores at baseline and end of treatment	Weekly administration of anabolic steroids during 6 weeks increased exercise capacity and quality of life in patients with COPD.

RCT = Randomized Control Trial