Table 4:

Summary of studies on TRT effect on Liver Cirrhosis

Authors, Year	Country	Study Design	Number of Participants	Intervention	Outcome of Interest	Study Findings
Yurci et al (2011)	Turkey	Prospective	12	50 mg Testogel/day Duration: 6 months	Muscle strength, hormones, profiles, and liver enzymes evaluated monthly; body composition parameters evaluated before and after 6 months	Testosterone treatment increased muscle strength and subscapular site subcutaneous fat tissue and decreased subareolar breast tissue without adverse effects
Sinclair et al (2016)	Australia	Prospective RCT	101	1000 mg testosterone undecanoate intramuscularly at 0, 6, 18, 20, and 42 weeks (Double-blinded, placebo – controlled trial) Duration: 12 months	Body composition assessed with dual-energy X-ray absorptiometry (DEXA) at baseline, 6 months, and 12 months	Testosterone increased appendicular lean mass; Testosterone therapy increased muscle mass, bone mass, and hemoglobin, and reduced fat mass and HbA1c

RCT = Randomized Control Trial