TABLE 2.
Microbiotas associated with different stages of NAFLDa
| Condition | Phylum | Family | Genus | Reference |
|---|---|---|---|---|
| NAFLD versus healthy controls | [Bacteroidetes] | Porphyromonadaceae ⇩ | Healthy (n = 30, BMI = 22)NAFLD (n = 30, BMI = 33)Raman et al., 2013 (35) | |
| [Firmicutes] | Veillonellaceae ⇧ | |||
| Lactobacillaceae ⇧ | Lactobacillus ⇧ | |||
| Ruminococcaceae ⇩ | Oscillibacter ⇩ | |||
| Lachnospiraceae ⇧ | Robinsoniella ⇧ | |||
| Roseburia ⇧ | ||||
| Dorea ⇧ | ||||
| [Proteobacteria] | Kiloniellaceae ⇧ | |||
| Pasteurellaceae ⇧ | ||||
| [Bacteroidetes] | [Rikenellaceae] | Alistipes ⇩ | Healthy (n = 32, BMI = 22)NAFLD (n = 53, BMI = 26)Jiang et al., 2015 (36) | |
| [Porphyromonadaceae] | Odoribacter ⇩ | |||
| [Firmicutes] | [Lactobacillaceae] | Lactobacillus ⇧ | ||
| [Oscillospiraceae] | Oscillibacter ⇩ | |||
| [Clostridiaceae] | Anaerobacter ⇧ | |||
| [Lachnospiraceae] | Clostridium XI ⇧ | |||
| [Streptococcaceae] | Streptococcus ⇧ | |||
| Flavonifractor ⇩ | ||||
| [Proteobacteria] | [Enterobacteriaceae] | Escherichia ⇧ | ||
| Lentisphaerae ⇩ | ||||
| NASH versus healthy controls | Bacteroidetes ⇩ | Healthy (n = 17, BMI = 26) | ||
| NASH (n = 22, BMI = 32) | ||||
| Mouzaki et al., 2013 (37) | ||||
| Bacteroidetes ⇧ | Prevotellaceae ⇧ | Prevotella ⇧ | Healthy (n = 16, BMI = 20)NASH (n = 22, BMI = 34)ChildrenZhu et al., 2013 (34) | |
| Rikenellaceae ⇩ | Allistipes ⇩ | |||
| Firmicutes ⇩ | Ruminococcaceae ⇩ | Oscillospira ⇩ | ||
| Ruminococcus ⇩ | ||||
| Lachnospiraceae ⇩ | Blautia ⇩ | |||
| Coprococcus ⇩ | ||||
| Eubacterium ⇩ | ||||
| Roseburia ⇩ | ||||
| Proteobacteria ⇧ | Enterobacteriaceae ⇧ | Escherichia coli ⇧ | Healthy (n = 22, BMI = 22)NASH (n = 16, BMI = 29)Wong et al., 2013 (38) | |
| Actinobacteria | Bifidobacteriaceae ⇩ | Bifidobacterium ⇩ | ||
| Firmicutes ⇩ | Unclassified Clostridiales ⇩ | Faecalibacterium ⇩ | ||
| [Ruminococcaceae] | Anaerosporobacter ⇩ | |||
| [Lachnospiraceae] | Allisonella ⇧ | |||
| [Veillonellaceae] | ||||
| [Bacteroidetes] | Porphyromonadaceae ⇧ | Parabacteroides ⇧ | ||
| [Proteobacteria] | Succinivibrionaceae ⇧ | |||
| NASH versus obese | Bacteroidetes ⇩ | [Lachnospiraceae] | Clostridium coccoides ⇧ | Obese (n = 11, BMI = 28) |
| NASH (n = 22, BMI = 32) | ||||
| [Firmicutes] | Mouzaki et al., 2013 (37) | |||
| Proteobacteria ⇧ | Enterobacteriaceae ⇧ | Escherichia coli ⇧ | Obese (n = 25, BMI = 33) | |
| NASH (n = 22, BMI = 34) | ||||
| Zhu et al., 2013 (34) | ||||
| NAFLD patients NASH versus no NASH | [Bacteroidetes] | Bacteroidaceae ⇧ | Bacteroides ⇧ | No NASH (n = 22, BMI = 30) |
| NASH (n = 35, BMI = 32) | ||||
| Boursier et al., 2016 (122) |
a
Microbiota were analyzed using 16S deep sequencing, except in the study by Mouzaki et al., in which qPCR was used. Additional taxonomic information for discriminating taxa is in brackets. Taxa in boldface are those identified in more than one study.