TABLE 1.

Selected Trp-derived indole compounds and their potential relationship to clinical phenomena in PV

Isolated compound	Pharmacological property	Phenomenon in PV
Pityriacitrin	UV protection	Lack of sunburn in depigmented areas of PV alba
Fluorescent metabolites (e.g., pityrialactone)	Fluorescence	Fluorescence of lesions in PV
Pityriarubins	Inhibition of oxidative burst in granulocytes	Lack of inflammation in lesions of PV
Malassezin	Induction of apoptosis in human melanocytes	Depigmentation in PV alba
AHRa-agonists (e.g., malassezin, pityriazepin, indolo[3,2-b]carbazole)	Activation of cytochrome, activation of AHR	Immunomodulation, effects on cell differentiation and homeostasis, depigmentation? desquamation?
Diversity of pigmented compounds	Pigmentation	Brick-red to brownish pigmentation of lesions in PV

^a AHR, aryl hydrocarbon receptor.