FIG. 6.

Histopathology of DE and PM single mutants and their corresponding triple mutants in the pancreas (Masson's trichrome stain). As described before, CVB3(T7) caused a complete necrosis of acinar tissue, and no regeneration was seen up to day 10 p.i. Both the DE (c) and PM (e) single mutants caused widespread damage to the exocrine pancreas, but islands of intact acini were present, and by day 10 these had enlarged to encompass >80% of the tissue (d and f, respectively). The triple mutants caused only minor damage to the pancreas, which was largely limited to tiny clusters of infected acinar cells associated with some lymphocytic infiltration on day 3 and essentially complete recovery of the tissue by day 10.