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(A) and (B) MTT assay to verify the drug resistance of the cells. (C) and (D) Transcriptome sequencing was performed to detect differences in miR-1247-3p expression in HCT8, HCT8/5-Fu and HCT8/DDP cells. (E) RT-qPCR was performed to verify the differential expression of miR-1247-3p in drug-resistant and parental cells. *P<0.05, **P<0.01, ***P<0.001. miR, microRNA; CRC, colorectal cancer; 5-Fu, 5-fluorouracil; DDP, cisplatin.
