FIG. 4.
Epigenetic regulation of CNTFRα expression. (A) Semiquantitative RT-PCR was performed with total RNA extracted from C58(NT)D cells treated with 5-azacytidine for 3 and 6 days. Semiquantitative RT-PCR (B) and Western blotting analysis (C top) with cell lysate from C58(NT)D cells treated with trichostatin A (TSA) and sodium butyrate (NaB) at the indicated concentrations for 12 h using specific primer and antibody for CNTFRα. (C, bottom) Time course experiment of CNTFRα gene expression induced by trichostatin A (100 ng/ml) and sodium butyrate (5 mM) treatment in C58(NT)D cells. GAPDH and actin served as internal controls.