Table 1.
Baseline characteristics of MESA participants by sex and phenogroup
| Men, n = 1995 | |||||
|---|---|---|---|---|---|
|
| |||||
| Variable | Phenogroup 1 (ideal cardiac mechanics) (n = 589) | Phenogroup 2 (higher output/ hypertrophied LV) (n = 673) | Phenogroup 3 (impaired EF/ dilated LV) (n = 359) | Phenogroup 4 (higher output/ hyperdynamic LV) (n = 374) | p-Value |
|
| |||||
| Age (years) | 64.9 (10.0) | 58.3 (9.5) | 60.3 (9.4) | 63.0 (9.7) | <.0001 |
| Ethnicity | |||||
| White | 188 (31.9%) | 304 (45.2%) | 146 (40.7%) | 131 (35.0%) | <.0001 |
| Chinese American | 145 (24.6%) | 29 (4.3%) | 32 (8.9%) | 47 (12.6%) | |
| Black | 140 (23.8%) | 186 (27.6%) | 89 (24.8%) | 88 (23.5%) | |
| Hispanic | 116 (19.7%) | 154 (22.9%) | 92 (25.6%) | 108 (28.9%) | |
| BMI (kg/m2) | 25.8 (3.9) | 28.9 (4.0) | 27.8 (3.9) | 27.4 (3.9) | <.0001 |
| Smoking status | |||||
| Never | 260 (44.3%) | 275 (40.9%) | 146 (40.9%) | 156 (41.7%) | 0.87 |
| Former | 251 (42.8%) | 299 (44.5%) | 156 (43.7%) | 167 (44.7%) | |
| Current | 76 (13.0%) | 98 (14.6%) | 55 (15.4%) | 51 (13.6%) | |
| Educational status | |||||
| Less than high school | 107 (18.2%) | 68 (10.1%) | 49 (13.7%) | 83 (22.2%) | <.0001 |
| High school or more | 480 (81.8%) | 604 (89.9%) | 308 (86.3%) | 291 (77.8%) | |
| Diabetes mellitus | 82 (13.9%) | 85 (12.6%) | 50 (13.9%) | 50 (13.4%) | 0.90 |
| Hypertension | 271 (46.0%) | 284 (42.2%) | 132 (36.8%) | 196 (52.4%) | 0.0002 |
| Heart rate (beats/min) | 63.9 (10.0) | 59.1 (9.1) | 62.2 (9.7) | 61.5 (9.5) | <.0001 |
| Systolic blood pressure (mmHg) | 124.8 (18.3) | 124.6 (18.8) | 121.9 (17.8) | 129.4 (20.2) | <.0001 |
| Fasting blood glucose (mg/dl) | 100.2 (29.9) | 96.2 (27.0) | 101.4 (36.4) | 100.1 (33.4) | 0.03 |
|
| |||||
| Women, N= 2209 | |||||
|
| |||||
| Variable | Phenogroup 1 (ideal cardiac mechanics) (n = 653) | Phenogroup 2 (higher output/ hypertrophied LV) (n = 679) | Phenogroup 3 (impaired EF/ dilated LV) (n = 429) | Phenogroup 4 (higher output/ hyperdynamic LV) (n = 448) | p-Value |
|
| |||||
| Age (years) | 65.2 (10.0) | 57.6 (8.9) | 61.4 (10.2) | 61.9 (9.8) | <.0001 |
| Ethnicity | |||||
| White | 261 (40.0%) | 256 (37.7%) | 176 (41.0%) | 183 (40.9%) | <.0001 |
| Chinese American | 140 (21.4%) | 35 (5.2%) | 51 (11.9%) | 43 (9.6%) | |
| Black | 127 (19.5%) | 247 (36.4%) | 113 (26.3%) | 122 (27.2%) | |
| Hispanic | 125 (19.1%) | 141 (20.8%) | 89 (20.8%) | 100 (22.3%) | |
| BMI (kg/m2) | 25.6 (4.6) | 31.0 (5.9) | 27.4 (4.7) | 28.5 (5.3) | <.0001 |
| Smoking status | |||||
| Never | 430 (66.2%) | 388 (57.3%) | 247 (57.7%) | 265 (59.4%) | 0.002 |
| Former | 167 (25.7%) | 207 (30.6%) | 116 (27.1%) | 133 (29.8%) | |
| Current | 53 (8.2%) | 82 (12.1%) | 65 (15.2%) | 48 (10.8%) | |
| Educational status | |||||
| Less than high school | 146 (22.5%) | 85 (12.6%) | 62 (14.5%) | 82 (18.4%) | <.0001 |
| High school or more | 504 (77.5%) | 592 (87.4%) | 366 (85.5%) | 364 (81.6%) | |
| Diabetes mellitus | 73 (11.2%) | 87 (12.8%) | 44 (10.2%) | 47 (10.5%) | 0.51 |
| Hypertension | 302 (46.3%) | 320 (47.1%) | 175 (40.8%) | 240 (53.6%) | 0.002 |
| Heart rate (beats/min) | 65.5 (9.2) | 63.2 (9.0) | 64.1 (8.9) | 62.6 (9.0) | <.0001 |
| Systolic blood pressure (mmHg) | 127.2 (23.0) | 124.5 (22.0) | 123.2 (22.2) | 128.5 (23.5) | 0.0009 |
| Fasting blood glucose (mg/dl) | 94.5 (27.3) | 94.5 (26.7) | 91.3 (24.2) | 93.6 (26.1) | 0.18 |
BMI = body mass index.
Continuous variables are presented as mean (standard deviation); categorical variables are presented as number (percentage).