Table 2.
Baseline measures of cardiac structure and function of MESA participants by sex and phenogroup
| Men, N = 1995 | |||||
|---|---|---|---|---|---|
|
| |||||
| Variable | Phenogroup 1 (ideal cardiac mechanics) n = 589 | Phenogroup 2 (higher output/ hypertrophied LV) n = 673 | Phenogroup 3 (impaired EF/ dilated LV) n = 359 | Phenogroup 4 (higher output/ hyperdynamic LV) n = 374 | p-Value |
|
| |||||
| Cardiac output (L/min) | 4.9 (1.1) | 6.9 (1.4) | 5.4 (1.1) | 6.4 (1.4) | <.0001 |
| Mean LV wall thickness, End-diastole (mm) | 10.1 (1.9) | 10.2 (1.6) | 10.5 (1.8) | 9.9 (1.9) | <.0001 |
| LV end-diastolic mass (g) | 118.9 (19.9) | 155.0 (25.2) | 141.4 (23.7) | 135.6 (23.2) | <.0001 |
| LV end-diastolic volume (mL) | 111.9 (17.1) | 171.2 (23.9) | 139.7 (19.6) | 138.9 (17.5) | <.0001 |
| LV end-systolic volume (mL) | 44.7 (10.7) | 65.7 (16.6) | 60.4 (15.1) | 49.5 (10.8) | <.0001 |
| LV ejection fraction (%) | 60.1 (6.1) | 61.9 (5.7) | 57.0 (6.3) | 64.5 (5.6) | <.0001 |
| LV stroke volume (mL) | 67.2 (11.7) | 105.5 (14.6) | 79.2 (11.5) | 89.5 (12.8) | <.0001 |
| RV diameter (mm) | 40.9 (5.2) | 47.8 (5.3) | 45.0 (5.4) | 44.2 (4.9) | <.0001 |
| RV end-diastolic volume (mL) | 110.2 (14.5) | 170.5 (21.1) | 143.8 (15.2) | 132.9 (13.1) | <.0001 |
| RV end-systolic volume (mL) | 34.8 (8.3) | 55.2 (12.6) | 53.9 (9.5) | 34.4 (5.6) | <.0001 |
| RV stroke volume (mL) | 75.4 (11.1) | 115.3 (15.8) | 89.9 (11.8) | 98.4 (10.6) | <.0001 |
| RV cardiac output (L/min) | 4.9 (1.2) | 6.8 (1.8) | 5.7 (1.3) | 6.3 (1.5) | <.0001 |
| RV ejection fraction (%) | 68.5 (5.9) | 67.7 (5.3) | 62.5 (5.0) | 74.1 (3.3) | <.0001 |
| RV end-diastolic mass (g) | 19.0 (2.3) | 27.0 (3.6) | 23.5 (2.8) | 22.0 (2.7) | <.0001 |
| Tricuspid annular plane systolic excursion (mm) | 16.6 (5.8) | 17.5 (4.9) | 16.7 (4.3) | 16.9 (4.7) | 0.18 |
|
| |||||
| Women, n = 2209 | |||||
|
| |||||
| Phenogroup 1 (ideal cardiac mechanics) n = 653 | Phenogroup 2 (higher output/ hypertrophied LV) n = 679 | Phenogroup 3 (impaired EF/ dilated LV) n = 429 | Phenogroup 4 (higher output/ hyperdynamic LV) n = 448 | p-Value | |
|
| |||||
| Cardiac output (L/min) | 4.7 (1.0) | 6.3 (1.4) | 4.9 (1.0) | 5.8 (1.2) | <.0001 |
| Mean LV wall thickness, end-diastole (mm) | 8.4 (1.5) | 8.7 (1.5) | 8.7 (1.7) | 8.6 (1.5) | <.0001 |
| LV end-diastolic mass (g) | 91.6 (15.1) | 118.4 (20.2) | 101.7 (17.2) | 107.6 (18.3) | <.0001 |
| LV end-diastolic volume (mL) | 95.4 (11.8) | 139.4 (19.4) | 110.1 (15.4) | 122.4 (15.2) | <.0001 |
| LV end-systolic volume (mL) | 34.9 (6.1) | 50.0 (10.6) | 43.2 (9.8) | 41.9 (9.6) | <.0001 |
| LV ejection fraction (%) | 63.2 (5.2) | 64.2 (5.0) | 60.8 (6.2) | 65.9 (5.4) | <.0001 |
| LV stroke volume (mL) | 60.4 (9.5) | 89.4 (13.9) | 66.9 (11.2) | 80.5 (11.1) | <.0001 |
| RV diameter (mm) | 37.7 (4.7) | 43.0 (4.7) | 39.8 (4.7) | 40.4 (4.6) | <.0001 |
| RV end-diastolic volume (mL) | 85.6 (10.9) | 134.0 (17.7) | 104.2 (11.2) | 110.4 (12.2) | <.0001 |
| RV end-systolic volume (mL) | 21.5 (4.7) | 40.0 (8.7) | 35.2 (6.3) | 24.1 (3.8) | <.0001 |
| RV stroke volume (mL) | 64.1 (8.9) | 94.0 (13.5) | 69.0 (8.7) | 86.3 (10.8) | <.0001 |
| RV cardiac output (L/min) | 4.4 (1.1) | 6.1 (1.5) | 4.4 (1.1) | 5.6 (1.4) | <.0001 |
| RV ejection fraction (%) | 74.9 (4.7) | 70.2 (4.6) | 66.2 (4.6) | 78.1 (3.0) | <.0001 |
| RV end-diastolic mass (g) | 15.9 (2.1) | 22.6 (3.1) | 18.8 (2.4) | 19.3 (2.3) | <.0001 |
| Tricuspid annular plane systolic excursion (mm) | 16.3 (4.9) | 16.6 (4.8) | 16.3 (4.0) | 17.4 (6.1) | 0.10 |
BMI = body mass index; LV = left ventricular; RV = right ventricular.
Continuous variables are presented as mean (standard deviation); categorical variables are presented as number (percentage).