TABLE 2.
Infectivity and replication of HIV chimeras
| Virion | Titer of BCFUa | Titer relative to NL4-3 | H9 replication (TCID/ml)b |
|---|---|---|---|
| sssDNAc | 1 | 3 × 10−6 | <1 |
| NL4-3 | 2.9 × 105 | 1 | ≥106 |
| PTAP− | 1.9 × 103 | 7 × 10−3 | <1 |
| HIV-p2b | 3.1 × 105 | 1.1 | ≥106 |
| HIV-KX | 1.0 × 103 | 3 × 10−3 | ≤101 |
| HIV-PPPPY | 3.4 × 102 | 1 × 10−3 | <1 |
a
Titer of blue cell-forming units (BCFU) per ml of clarified transfection supernatant.
b
Tissue culture infective dose (TCID) per ml as measured by infecting H9 cells with 10-fold dilutions of clarified transfection supernatant. The highest dilution tested was 10−7.
c
sssDNA, virus preparation from a sheared salmon sperm DNA transfection.