TABLE 1.
Genes determined by ChIP to be Myc targets (www.myccancergene.org) and genes up-regulated by Myc in P493-6 cells as determined by microarray analysis
| Gene function | Gene determined by:
|
Fold inductionb | |
|---|---|---|---|
| ChIPa | Microarray | ||
| Oxidoreductase activity | NDUFA1 | ||
| NDUFA2 | |||
| NDUFB3 | |||
| NDUFB5 | |||
| NDUFS1 | NDUFS1 | 2.5 | |
| NDUFS6 | NDUFS6 | 2.2 | |
| NDUFV1 | |||
| PRDX3 | PRDX3 | 2.1 | |
| Ion transport | UCP1 | ||
| UCP3 | |||
| DNA metabolism | PHB | PHB | 5.0 |
| TFAM* | TFAM | 3.0 | |
| Protein metabolism | HSPD1 | HSPD1 | 5.3 |
| HSPE1 | HSPE1 | 5.3 | |
| TIMM17A | TIMM17A | 3.0 | |
| UQCRC2 | |||
| Amino acid metabolism | SHMT2 | SHMT2 | 3.1 |
| Tricarboxylic acid cycle | ACBP | ||
| DBI | |||
| Inner mitochondrial membrane | CYCS | CYCS | 3.4 |
| FCI-12 | |||
| TIMM10* | TIMM10 | 2.7 | |
| Other | NME1 | NME1 | 8.8 |
| MCFP | |||
| HAX1 | |||
a
The genes marked with an asterisk are genes bound by dMyc as determined by global genomic mapping in Drosophila.
b
Fold induction determined by microarray analysis between ectopic and low-Myc states.