TABLE 1.

MHC-CELFΔ hearts are functionally impaired at 9 weeks

Method of measurement (units)	Wild type (n = 6)	MLC-CELFΔa (n = 6)
M-mode echocardiography
Diastolic dimension (mm)	3.33 ± 0.18	4.14 ± 0.16*
Systolic dimension (mm)	2.05 ± 0.09	3.27 ± 0.22*
Posterior wall thickness (mm)	0.86 ± 0.06	1.03 ± 0.05
Fractional shortening	0.38 ± 0.02	0.21 ± 0.03*
Vcfcb (s−1)	2.17 ± 0.22	1.31 ± 0.22*
10-mHz Doppler
Heart rate (beats/min)	391 ± 19	366 ± 23
SD of RR interval (ms)	3.2 ± 1.1	1.8 ± 0.2*
Systolic parameters
Peak aortic flow velocity (cm/s)	114.2 ± 2.8	62.5 ± 4.0*
Mean acceleration (cm/s2)	7,984 ± 399	3,355 ± 280*
Peak acceleration (cm/s2)	19,040 ± 1,420	6,980 ± 940*
Ejection time (ms)	62.5 ± 0.8	59.3 ± 2.4
Isovolumic contraction time (ms)	11.6 ± 0.4	18.2 ± 3.6*
Diastolic parameters
Peak early-filling velocity (cm/s)	97.7 ± 4.9	79.7 ± 9.4*
Isovolumic relaxation time (ms)	14.4 ± 1.0	19.2 ± 3.33*
Tei indexc	0.42 ± 0.02	0.69 ± 0.13*

^aAsterisk indicates mean is significantly different from that of the wild type (P ≤ 0.05).

^bVcfc, rate-corrected mean velocity of circumferential fiber shortening = (fractional shortening × square root of the RR interval)/ejection time.

^cTei index = (isovolumic contraction time + isovolumic relaxation time)/ejection time.