TABLE 1.
Method of measurement (units) | Wild type (n = 6) | MLC-CELFΔa (n = 6) |
---|---|---|
M-mode echocardiography | ||
Diastolic dimension (mm) | 3.33 ± 0.18 | 4.14 ± 0.16* |
Systolic dimension (mm) | 2.05 ± 0.09 | 3.27 ± 0.22* |
Posterior wall thickness (mm) | 0.86 ± 0.06 | 1.03 ± 0.05 |
Fractional shortening | 0.38 ± 0.02 | 0.21 ± 0.03* |
Vcfcb (s−1) | 2.17 ± 0.22 | 1.31 ± 0.22* |
10-mHz Doppler | ||
Heart rate (beats/min) | 391 ± 19 | 366 ± 23 |
SD of RR interval (ms) | 3.2 ± 1.1 | 1.8 ± 0.2* |
Systolic parameters | ||
Peak aortic flow velocity (cm/s) | 114.2 ± 2.8 | 62.5 ± 4.0* |
Mean acceleration (cm/s2) | 7,984 ± 399 | 3,355 ± 280* |
Peak acceleration (cm/s2) | 19,040 ± 1,420 | 6,980 ± 940* |
Ejection time (ms) | 62.5 ± 0.8 | 59.3 ± 2.4 |
Isovolumic contraction time (ms) | 11.6 ± 0.4 | 18.2 ± 3.6* |
Diastolic parameters | ||
Peak early-filling velocity (cm/s) | 97.7 ± 4.9 | 79.7 ± 9.4* |
Isovolumic relaxation time (ms) | 14.4 ± 1.0 | 19.2 ± 3.33* |
Tei indexc | 0.42 ± 0.02 | 0.69 ± 0.13* |
Asterisk indicates mean is significantly different from that of the wild type (P ≤ 0.05).
Vcfc, rate-corrected mean velocity of circumferential fiber shortening = (fractional shortening × square root of the RR interval)/ejection time.
Tei index = (isovolumic contraction time + isovolumic relaxation time)/ejection time.