TABLE 1.

Effect of TBH, Nrf1, Nrf2, Fra-1, and Fra-1 antisense treatments on cell GSH levels

Treatment	Cell GSH level, nmol/mg proteina
	WT	F1	F2
Control	46.9 ± 2.7	37.9 ± 0.8†	25.3 ± 1.0†
TBH	87.1 ± 1.5*	67.7 ± 1.7**	41.7 ± 1.6**
Fra-1	36.3 ± 1.2**	32.3 ± 1.3*	16.8 ± 0.5**
Fra-1 antisense	80.7 ± 6.2**	53.4 ± 3.9*	44.6 ± 5.1*
Nrf1		60.9 ± 2.6**
Nrf2			47.1 ± 7.6*

^aResults represent the mean ± SE from three experiments done in triplicate. WT, F1, and F2 cells were treated with TBH (60 μM for 8 h), Fra-1, Fra-1 antisense, Nrf1, or Nrf2 expression vectors for 12 h as described in Materials and Methods. *, P < 0.05 versus controls; **, P < 0.01 versus controls; †, P < 0.05 versus WT control by ANOVA followed by Fisher's test.