Table 1.
Baseline demographics and characteristics between patients with gender dysphoria (GD) and no documented gender-affirming medical therapy (no GAMT) versus patients with GD and with any documented GAMT
| Characteristic | Overall (GD diagnosis) N = 90,955 | NI N = 34,556 |
Any GAMT (HT or SX) N = 56,399 | HT N = 52,699 |
SX N = 10,537 |
p-value |
|---|---|---|---|---|---|---|
| Age at diagnosis | 25.8 ± 13.3 | 24.6 ± 14.6 | 26.6 ± 12.4 | 26.4 ± 12.5 | 28.5 ± 11.8 | <0.001 |
| Unknown | 63 | 52 | 11 | 10 | 2 | |
| Median length since GID Diagnosis (days) | 675 | 370 | 908 | 952 | 510 | |
| Sex at birth | <0.001 | |||||
| Female | 51,896 (57.1%) | 20,420 (59.1%) | 31,476 (55.8%) | 28,890 (54.8%) | 6954 (66.0%) | |
| Male | 38,082 (41.9%) | 13,816 (40.0%) | 24,266 (43.0%) | 23,224 (44.1%) | 3421 (32.5%) | |
| Unknown | 977 (1.1%) | 320 (0.9%) | 657 (1.2%) | 585 (1.1%) | 162 (1.5%) | |
| Race | <0.001 | |||||
| American Indian or Alaska Native | 773 (0.8%) | 307 (0.9%) | 466 (0.8%) | 440 (0.8%) | 78 (0.7%) | |
| Asian | 2110 (2.3%) | 828 (2.4%) | 1282 (2.3%) | 1208 (2.3%) | 252 (2.4%) | |
| Black or African American | 7256 (8.0%) | 3119 (9.0%) | 4137 (7.3%) | 3882 (7.4%) | 787 (7.5%) | |
| Native Hawaiian or Other Pacific Islander | 309 (0.3%) | 166 (0.5%) | 143 (0.3%) | 138 (0.3%) | 20 (0.2%) | |
| White | 63,204 (69.5%) | 23,139 (67.0%) | 40,065 (71.0%) | 37,569 (71.3%) | 1994 (18.9%) | |
| Unknown | 17,303 (19.0%) | 6997 (20.2%) | 10,306 (18.3%) | 9462 (18.0%) | 7406 (70.3%) | |
| Ethnicity | <0.001 | |||||
| Hispanic or Latino | 7298 (8.0%) | 2937 (8.5%) | 4361 (7.7%) | 4123 (7.8%) | 815 (7.7%) | |
| Not Hispanic or Latino | 63,113 (69.4%) | 22,787 (65.9%) | 40,326 (71.5%) | 37,966 (72.0%) | 7396 (70.2%) | |
| Unknown | 20,544 (22.6%) | 8832 (25.6%) | 11,712 (20.8%) | 10,610 (20.1%) | 2326 (22.1%) | |
| BMI | 26.2 ± 7.3 | 25.4 ± 7.4 | 26.6 ± 7.2 | 26.5 ± 7.2 | 27.8 ± 6.9 | <0.001 |
| Unknown | 59,812 | 23,054 | 36,758 | 34,482 | 6554 | |
| Pre-existing conditions | ||||||
| Eating disorder | 1943 (2.1%) | 1112 (3.2%) | 831 (1.5%) | 804 (1.5%) | 108 (1.0%) | <0.001 |
| Anxiety | 24,510 (26.9%) | 11,518 (33.3%) | 12,992 (23.0%) | 12,482 (23.7%) | 1945 (18.5%) | <0.001 |
| Obsessive Compulsive Disorder | 1586 (1.7%) | 820 (2.4%) | 766 (1.4%) | 731 (1.4%) | 115 (1.1%) | <0.001 |
| Type II Diabetes Mellitus | 3163 (3.5%) | 1580 (4.6%) | 1583 (2.8%) | 1511 (2.9%) | 224 (2.1%) | <0.001 |
| Body dysmorphic disorder | 167 (0.2%) | 92 (0.3%) | 75 (0.1%) | 71 (0.1%) | 9 (0.1%) | <0.001 |
| Depression | 10,216 (11.2%) | 4538 (13.1%) | 5678 (10.1%) | 5404 (10.3%) | 947 (9.0%) | <0.001 |
(± refers to 1 SD from the mean).