FIG. 2.

Comparison of two types of PPTases among apicomplexans and other groups of organisms. SFP-PPTs are present in bacteria, type I FAS-containing apicomplexans, fungi, animals, and plants. Some plant SFP-PPTs may contain an N-terminal mitochondrium-targeting signal (open box in parenthesis). ACPS-PPTs are present in bacteria, plastid-containing apicomplexans, and fungi. Apicomplexan ACPS-PPTs are bifunctional and contain plastid-targeting signals (open box). Fungal ACPS-PPTs are present as a C-terminal domain in the α-subunit of fatty acid synthase (FAS2). PSSM logos include two motifs for all PPTases, one specific to SFPs and one for hydrolases.