. 2005 Jul;4(7):1211–1220. doi: 10.1128/EC.4.7.1211-1220.2005

TABLE 1.

Correlation between the types of PPTases and FAS/PKS in apicomplexans

Organism	Type of FAS/PKS	PPTase^a	Signal peptide in PPTases	Prediction method
Organism	Type of FAS/PKS	PPTase^a	Signal peptide in PPTases	PlasmoAP^b	ChloroP^c	PlasMit^d
P. falciparum	Type II FAS	PfACPS-PPT	Plastid	Yes	No	No^f
C. parvum	Type I FAS and PKS	CpSFP-PPT	No	No	No	No^f
T. gondii	Type II FAS	TgACPS-PPT	Plastid	No^e	Yes	No^f
T. gondii	Type I FAS	TgSFP-PPT	No	No	No	No^f

Sources of apicomplexan PPTase protein sequences: CpSFP-PPT (GenBank accession no. AY856092) was annotated from cDNA in this study; PfACPS-PPT (NP_702851) was identified in GenBank by BLAST searches; TgSFP-PPT (contig TGG_995284) and TgACPS-PPT (TgTwinScan_3790) were identified from raw genome sequences at ToxoDB, release 3.0 (http://www.toxodb.org). Also see the supplemental material for conceptually translated TgSFP-PPT and TgACPS-PPT sequences.

http://www.plasmodb.org/restricted/PlasmoAPcgi.shtml.

http://www.cbs.dtu.dk/services/ChloroP/.

http://gecco.org.chemie.uni-frankfurt.de/plasmit/.

PlasmoAP is trained for predicting plastid-targeting sequences in the AT-rich P. falciparum genes and may not be able to accurately predict sequences from other species including T. gondii.

All sequences are predicted to be 99% unlikely to contain mitochondrium-targeting signals.