TABLE 4.
Characteristics of patients according to SAFE score with the whole study series and for propensity score‐matched study.
| Whole study series | Propensity score‐matched series | |||||
|---|---|---|---|---|---|---|
| High‐SAFE score group (n = 225) | Low‐SAFE score group (n = 182) | p‐Value | High‐SAFE score group (n = 108) | Low‐SAFE score group (n = 108) | p‐Value | |
| Sex (M/F) | 165/60 | 153/29 | 0.009 | 89/19 | 87/21 | 0.726 |
| Liver background: HCV | 131 (58.2%) | 76 (41.8%) | 0.001 | 55 (50.9%) | 56 (51.9%) | 0.892 |
| Liver background: HBV | 17 (7.5%) | 62 (34.1%) | <0.001 | 15 (13.9%) | 14 (13.0%) | 0.842 |
| T‐Bil (mg/dL) | 0.8 (0.6–1.0) | 0.7 (0.6–1.0) | 0.103 | 0.7 (0.6–1.0) | 0.7 (0.6–0.9) | 0.549 |
| PT (%) | 83 (75–91) | 90 (84–98) | <0.001 | 87 (79–95) | 89 (81–96) | 0.489 |
| ICG‐R15 (%) | 16.5 (11.2–22.8) | 9.8 (6.6–15.7) | <0.001 | 13.7 (9.4–18.5) | 12.3 (8.3–17.7) | 0.192 |
| AFP (ng/mL) | 9.7 (4.8–45.1) | 7.7 (3.8–84.5) | 0.660 | 9.8 (3.6–70.2) | 6.8 (3.7–50.9) | 0.573 |
| DCP (mAU/mL) | 41.5 (20.0–344) | 44.0 (21.0–425) | 0.459 | 46.5 (20.0–408) | 51 (22.0–705) | 0.497 |
| Tumor number | 1 (1–10) | 1 (1–13) | 0.016 | 1 (1–5) | 1 (1–7) | 0.677 |
| Tumor diameter (mm) | 24.0 (16.0–35.0) | 25.0 (16.8–44.3) | 0.347 | 28.5 (20.0–44.8) | 26.0 (19.0–51.0) | 0.925 |
| Histology: poorly differentiation | 17 (7.6%) | 25 (13.7%) | 0.042 | 12 (11.1%) | 13 (12.0%) | 0.832 |
| Vascular invasion: Vp (+) | 34 (15.2%) | 30 (16.6%) | 0.702 | 20 (18.7%) | 15 (14.0%) | 0.355 |
| Vascular invasion: Vv (+) | 13 (5.9%) | 11 (6.1%) | 0.926 | 10 (7.6%) | 9 (6.8%) | 0.825 |
| IM (+) | 16 (7.1%) | 20 (11.1%) | 0.170 | 6 (5.6%) | 11 (10.3%) | 0.206 |
| Operative time (min) | 315 (247–391) | 301 (245–372) | 0.584 | 329 (266–408) | 302 (251–370) | 0.086 |
| Intraoperative blood loss (mL) | 380 (178–650) | 279 (129–551) | 0.017 | 390 (173–648) | 311 (133–574) | 0.167 |
| Intraoperative blood transfusion (+) | 20 (8.9%) | 8 (4.4%) | 0.069 | 8 (7.4%) | 6 (5.6%) | 0.580 |
| Postoperative complications CD ≥3 | 30 (13.3%) | 13 (7.1%) | 0.040 | 8 (7.4%) | 10 (9.3%) | 0.623 |
Note: The variables in bold are statistically significant (p < 0.05). Continuous variables are expressed as medians (interquartile ranges: only tumor number is range). Qualitative variables are expressed as numbers (%).
Abbreviations: AFP, α‐fetoprotein; CD, Clavien–Dindo; DCP, des‐gamma‐carboxy prothrombin; F, female; HBV, hepatitis B virus; HCV, hepatitis C virus; ICG‐R15, indocyanine green dye retention rate at 15 min; IM, intrahepatic metastasis; M, male; PT, prothrombin time; SAFE score, steatosis‐associated fibrosis estimator score; T‐Bil, total‐bilirubin; Vp, portal vein invasion; Vv, hepatic venous invasion.