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. 2024 Jul 29;56(12):1813–1822. doi: 10.3724/abbs.2024122

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© The Author(s) 2021.

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).

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Enzymatic inhibition of SARS-CoV-2 M ^pro and SARS-CoV-2 M ^pro mutants by PF-00835231

(A) Inhibitory potency of PF-00835231 against the main protease of the SARS-CoV-2 Mpro K90R. (B) Inhibition of PF-00835231 by the main protease of SARS-CoV-2 Mpro M49I. (C) Inhibition of the main protease of SARS-CoV-2 Mpro G15S by PF-00835231. (D) Inhibition of PF-00835231 against the main protease of SARS-CoV-2 Mpro V186F. (E) Inhibition of PF-00835231 against the main protease of SARS-CoV-2 Mpro P132H. (F) Inhibition of PF-00835231 against the main protease of SARS-CoV-2 Mpro Y54C.