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. 2024 Jul 29;56(12):1813–1822. doi: 10.3724/abbs.2024122

Figure 3 .

Figure 3

Structural overview of M pro mutants from SASR-CoV-2 in complex with PF-00835231

(A) Overall structure of the Mpro G15S-PF-00835231 complex. The G15S mutant is shown as an orange cartoon, while PF-00835231 is displayed as a stick. (B) Overall structure of the Mpro K90R-PF-00835231 complex. K90R mutant in slate cartoons, while PF-00835231 is displayed in stick representation. (C) Overall structure of the Mpro M49I-PF-00835231 complex. The M49I mutant is shown as a gray 90 cartoon, while PF-00835231 is displayed as a stick. (D) Overall structure of the Mpro P132H-PF-00835231 complex. P132H mutant in a salmon cartoon, while PF-00835231 is displayed as a stick. (E) Overall structure of the M pro S46F-PF-00835231 complex. The S46F mutant is shown as a light blue cartoon, while PF-00835231 is displayed as a stick. (F) Overall structure of the Mpro V186F-PF-00835231 complex. The V186F mutant is shown as a yellow cartoon, while PF-00835231 is displayed as a stick. (G) Overall structure of the Mpro Y54C-PF-00835231 complex. The Y54C mutant is shown as a green cartoon, while PF-00835231 is displayed as a stick.