TABLE 1.

Distribution by age of diagnosis weighted by mutation probabilities for individuals diagnosed with colorectal or endometrial cancer by generation, birth cohort, mismatch repair proficiency, and mismatch repair deficiency.

	Total no.	No. affected (%)	Age of diagnosis: Mean ± SD, years	Age of diagnosis: Median [IQR], years
Generation, N = 668
Grandparents	129	21 (16.3)	52.6 ± 14.0	48 [23]
Parents	193	48 (24.9)	46.3 ± 12.2	45 [15]
Probands	218	53 (24.3)	40.1 ± 11.9	40 [15]
Children	128	17 (13.2)	42.1 ± 8.4	40 [13]
Cohort, N = 656
<1920	82	19 (23.2)	45.5 ± 11.0	42 [10]
1920–1939	140	38 (27.1)	53.1 ± 13.5	50 [13]
1940–1959	173	51 (29.0)	42.9 ± 10.3	44 [13]
1960–1979	164	26 (15.9)	39.6 ± 6.9	39 [10]
1980–2000	97	7 (7.2)	25.7 ± 6.4	24 [8]
MMR‐proficient, N = 158
Grandparents	31	5 (16.1)	58.5 ± 20.7	42 [26]
Parents	46	7 (15.2)	46.0 ± 12.6	45 [16]
Probands	56	3 (5.3)	36.6 ± 15.4	31 [26]
Children	23	0 (0.0)	—	—
MMR‐deficient, N = 310
Grandparents	50	5 (10.0)	52.3 ± 10.5	47 [3]
Parents	89	26 (29.2)	45.3 ± 10.7	44 [13]
Probands	86	28 (32.5)	42.9 ± 13.6	40 [13]
Children	56	12 (21.4)	43.9 ± 8.1	39.5 [9]

Abbreviations: IQR, interquartile range; MMR, mismatch repair; SD, standard deviation.