Table 2.

Cannabinoid hyperemesis syndrome in pregnancy cases, adapted with permission from Flament et al. ⁶

Number	Ref.	Age, y	Obstetric status	Gestation symptoms started, weeks; days	Initial diagnosis hyperemesis gravidarum	Nausea and vomiting + cannabis use + hot shower/bath	Hot bathing effect	Cannabis use history (how long/how many times per week)	Psychiatric history	Delivery
1	Case 1	30	G3P1	5	No	All 3	Beneficial	5 years/every 3–4 days	Generalised anxiety disorder	38 + 5 induction of labour, 2105 g, Apgar 9/10, 10/10, normal paediatric review, no NICU, discharge day 2
2	Case 2	28	G2P0 + 1	16	No	All 3	Beneficial	14 years	Depression and anxiety	37 weeks, SVD, 2180 g, Apgar 9/10. 5 days NICU, IUGR, group B Strep infection
3	La Sala et al. 13	40	G2P0A1	8	No	All 3	Beneficial	27 years/1 g daily	Nil	Born full term, no complications
4	Abreu Jáuregui et al 8	24	G3P0A2	8	?	All 3	Beneficial	Yes, ‘habitually consumed’	Anxiety disorder	23 weeks, died 12 h later in NICU due to complications of prematurity
5	Flament et al 6	29	G1P0A0	29	?	All 3	Beneficial	6 years/daily	Nil	39 wks 6/7 2650 g No complications. Hospital discharge on the third day in good condition
6	Nguyen et al 12	19	?	20	No	All 3	Beneficial	Daily cannabis use, number of years not stated	Nil	? Patient lost to follow-up
7	Justi et al. 2018 10	19	G3P1A1	32	?	All 3	Beneficial	4 years/daily	Nil	35 weeks, mild respiratory distress but rapid resolution
8	Kim et al 9	20	G7P0A6	14; 3/7	?	All 3	Beneficial	?	Depression and bipolar disorder, 3× psychiatric admissions on this pregnancy for agitation + vomiting	40 wks 3/7 3190 g APGAR 8/9 No complications described
9	Manning Meurer et al 11	21	G1P0A0	6	Yes	2/3 Shower/bath not described	?	?	Nil	Induced at 36 wks 6/7 for pre-eclampsia. 2430 g Fetal deceleration Shoulder dystocia APGAR 1/5 19 days in NICU Baby intracranial haemorrhage and spontaneous resorption. At 10 months of life, normal baby evolution
10	Alaniz et al. 7	28	G5P3A1	30; 5/7	Yes	All 3	Beneficial	12 years/daily	?	NICU for hypoxia. Hospital discharge on the second day in good condition
11	Andrews et al 15	24	G5P2A2	26; 2/7	Yes	All 3	Beneficial	8 years/several times per week	?	37 wks 2270 g APGAR 9/9; No complications described
12	Swanson et al 16	33	‘multiparous’	7	?	All 3	Beneficial	1 year/twice daily	Nil	Term, healthy
13	Schmid et al. 2011 55	26	G2P0A1	10	Yes	All 3	Beneficial	13 years/daily	History of psychiatric hospitalisation ‘psychogenic vomiting’	Uncomplicated

The symbol [?] indicates no data available.

NICU: neonatal intensive care unit; y: years; wks: weeks; g: grams.