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Core biopsy of the lung right middle lobe. Cores contained focal malignant cells with clear cytoplasm (*) which showed cytologic architecture consistent with carcinoma (a, 4×; b, 20×). Immunohistochemical staining revealed the clear cells were positive for PAX8 (c) and carbonic anhydrase (CAIX) (d). This immunophenotype is characteristic of RCC.
