Fig. 3. In vivo micro-CT morphometric analysis.

Quantitative morphometric analyses (n = 2 per group) were performed in four volumes of interest: the defect center (DC), the defect periphery (DP), the existing fracture cortex and medullary cavity (FC), and the cortex periphery (FP). Two parameters are presented: (A to D) BV/TV where the bone volume (BV) is normalized to TV (DC for DC and DP, FC for FC and FP). (E to H) Bone formation rates (BFR) and bone resorption rates (BRR). Shaded regions in each plot correspond to time points at which loading was applied 3× per week.