Fig. 8. Use of the coefficient of variation (CV) to analyze transcriptomic responses of cells with respect to their local in vivo mechanical environment.

Data presented (n = 1 per group) correspond to the mechanically loaded fracture site at 5 weeks after surgery. Use of the coefficient of variation (CV) to identify the top 25 genes of functional significance within each strain region. Genes associated with bone formation are identified in orange. Genes associated with bone resorption are identified in purple. Genes that are inhibitors of bone formation/resorption or genes that have roles in both bone formation/resorption are identified by alternating lines/hatches in orange and purple.