FIGURE 3.

CoV072 induces a Th1‐biased cellular immune response in mice. Intracellular cytokine staining was performed to detect Th1/Th2 bias in the CoV072‐induced cellular immune response. S protein peptide libraries from Omicron BA.4/5, XBB.1.5, and EG.5.1 were used to stimulate mouse splenic lymphocytes, and the (A) IFN‐γ, (B) IL‐2, (C) IL‐4, and (D) IL‐10 levels secreted from CD8+ T cells were determined. N = 5, geometric mean ± geometric standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns: p > 0.05.