FIGURE 6.

The applications of cellular targeted delivery. (A) Dendritic cells. Glucosylated nanovaccines targeting Glut‐1 on DCs deliver both conventional antigens and tumor‐specific neoantigens, triggering DCs maturation and robust adaptive immune responses. (B) T cells. The synthesis of LNPs engineered to transport mRNA to T cells was achieved by substituting cholesterol with hydroxycholesterol within their structure and design. ²²⁸ (C) Macrophages. The dual targeting of both tumor cells and tumor‐associated macrophages in breast cancer therapy developed by utilizing folate receptors highly expressed on these cells. ²³⁴ (D) Tumor cells. Lipid–peptide nanocomplexes to deliver mRNA to the murine B16‐F10 melanoma tumor. ²³⁵