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. 2024 Dec 20;11:1511682. doi: 10.3389/fnut.2024.1511682

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Copyright © 2024 Liang, Zhang, Cheng, Yuan, Yang, Yi, Li, Zhang, Sun, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sesamin enhances mitophagy and alleviates lipid accumulation in L02 cells. (A) Mitochondrial microstructure and lipid droplet accumulation observation by TEM. The red and green boxes represent enlarged images of representative parts; (B) Volume ratio of oil droplets in cells; (C) Number of pyknotic mitochondria; (D) Number of autophagic lysosomes; N: Nucleus; M: Mitochondria; LD: lipid droplets; The green arrow represents pyknotic mitochondria; The red arrow represents autolysosomes. Control: RPMI 1640 complete culture medium; Model: 500 μM 9-trans-C18:1 + RPMI 1640; S32: 500 μM 9-trans-C18:1 + 32 μM sesamin. All data were represented as means ± SD (n = 6), *p < 0.05; **p < 0.01.