Table 2.

Pharmacokinetic parameters of ABZ-pHs-SD and ABZ-G^® in rats.

Parameters	Unit	ABZ		ABZSO		ABZSO2
		ABZ-G®	ABZ-pHs-SD	ABZ-G®	ABZ-pHs-SD	ABZ-G®	ABZ-pHs-SD
Tmax	h	2.00 ± 2.04	3.89 ± 2.03	3.75 ± 0.71	5.5 ± 0.93**	8.75 ± 2.82	11 ± 1.85
Cmax	ug/mL	0.19 ± 0.07	0.10 ± 0.05**	6.83 ± 0.66	4.70 ± 1.16**	1.47 ± 0.67	1.05 ± 0.25
t1 /2	h	2.18 ± 0.06	3.25	85.93 ± 32.06	97.28 ± 46.52	62.60 ± 40.08	33.82 ± 23.12
AUC0−t	h* ug /mL	0.65 ± 0.22	0.38 ± 0.21*	45.87 ± 3.44	41.52 ± 9.83	22.36 ± 4.13	25.50 ± 9.44
AUC0−∞	h* ug /mL	0.77 ± 0.21	0.55	54.26 ± 6.92	51.14 ± 14.86	25.79 ± 4.16	28.01 ± 9.38
MRT	h	2.83 ± 0.59	3.68 ± 1.30**	11.87 ± 0.88	14.01 ± 2.00*	19.93 ± 3.94	27.32 ± 5.76**
Ke	1/h	0.32 ± 0.01	0.21	0.009 ± 0.003	0.008 ± 0.003	0.018 ± 0.017	0.027 ± 0.015

* indicates p < 0.05, ** indicates p < 0.01 compared to ABZ-G^®.