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. 2024 Dec 20;15:1479181. doi: 10.3389/fimmu.2024.1479181

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Copyright © 2024 Huang, Feng, Huang, Zhang and Liao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The overlapped roles of sialoglycans in pregnancy and tumor. The maternal-fetal immunity shared similar mechanisms with tumor immunity. (A) Sialoglycans regulate maternal-fetal immunity. (B) Sialoglycans are involved in tumor infiltration and invasion. For example, sialoglycans on tumor cells induce EMT and endothelial activation, allowing infiltration and invasion. (C) Sialoglycans help the survival of tumor cells during their bloodstream and lymphatic transportation and the establishment of secondary tumor sites.