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. 2024 Dec 20;18:1520710. doi: 10.3389/fnins.2024.1520710

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Copyright © 2024 Yao, Hu, Li, Wang, Pan and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TREM2 shRNA successfully decreased the expression of TREM2 in the hippocampus on day 21 after the injection of TREM2 shRNA. (A,B) The expression of TREM2 protein in the hippocampus (n = 3). (C,D) The expression of DAP12 protein in the hippocampus (n = 3). (E) The expression of TREM2 mRNA in the hippocampus (n = 3). (F) The expression of DAP12 mRNA in the hippocampus. ns: no significant; *p < 0.05, ***p < 0.001, the SE + vehicle group vs. the SE + shRNA group; ##p < 0.01, ###p < 0.001, the EE+ vehicle group vs. the EE+ shRNA group. Error bars were represented as mean ± SD.