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. 2024 Dec 20;15:1517679. doi: 10.3389/fimmu.2024.1517679

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Copyright © 2024 Wang, Zhao, Zhang, Sun, Xiahou, Wang, Liu and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro experiments confirmed the effects of IRX4 knockdown. (A) Decreased mRNA and protein expression levels after IRX4 knockdown. (B) CCK-8 assay showed a significant decrease in cell viability after IRX4 knockdown compared to the control group. (C, D) Colony formation assay demonstrated a significant decrease in colony numbers after IRX4 knockdown. (E) EDU staining experiment confirmed the inhibitory effect of IRX4 knockdown on cell proliferation. (F) Wound healing assay showed that IRX4 knockdown inhibited cell migration. (G) Bar graph displayed a significant decrease in cell proliferation and migration abilities after IRX4 knockdown. (H, I) Transwell assay showed that IRX4 knockdown suppressed the migration and invasion abilities of tumor cells in MDA PCA 2b and VCap cell lines. **P<0.01, ***P<0.001.