Fig. 7. PheWAS results for SLE case-control and progression risk scores in UK Biobank.

A PheWAS results for CC-PRS of SLE. B PheWAS results from GPS-PRS of SLE. The y-axis represents the −log10(p-value) for each PheWAS code, derived using a two-sided Chi-square test after fitting a multivariate logistic regression model. The x-axis displays different PheWAS code categories. Each point corresponds to a specific PheWAS code, with downward and upward-pointing triangles indicating negative and positive associations between the disease status defined by the PheWAS code and the PRS, respectively.