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. 2025 Jan 2;16:180. doi: 10.1038/s41467-024-55636-6

Table 3.

ICD codes used to define RA and SLE disease status

Disease ICD codes
Rheumatoid Arthritis (RA)

ICD9: 714.0, 714.1, 714.2, 714.81

ICD10: M05*, M06.8*, M06.9

Systemic lupus erythematosus (SLE)

ICD9: 710.0

ICD10: M32.8, M32.9, M32.1*

Seropositive (ANA or RF positive) Individuals with relevant diagnostic codes are defined as disease cases56, following established algorithms. The remaining seropositive individuals with no diagnostic codes for the disease at any time in the EHR but being followed up are considered non-progressed controls.

ICD codes ending in “*” include all sub-level codes. e.g., M32.1* code contains all sublevel codes such as M32.10, M32.11, M32.12, M32.13, M32.14, etc.