Fig. 1. Schematic showing the method to generate the retinal pigmentation score (RPS) from a colour fundus image.

Input images are fed into the deep learning algorithm to generate segmentation masks. These are added together to make a retinal background mask, which is then transformed into L,a,b colorspace. The chromaticity vectors are then extracted and transformed by the principal component analysis model to create the RPS. Created with Biorender.com.