Fig. 4. Assessment of Compound 3 efficacy in therapeutic APOL1 G2_sc mouse model of APOL1-mediated kidney disease.

A Assessment of urinary albumin-to-creatinine ratio (UACR) in response to hydrodynamic injection of IFNγ plasmid in APOL1 G2_sc transgenic mice over 14 days. n = 12 (Vehicle) and n = 11 (Compound 3). Vehicle group had 5 F and 7 M; Compound 3 group had 6 F and 5 M. B UACR area under the curve (AUC) showed reduced proteinuria in Compound 3-treated mice. One male Vehicle mouse was excluded from UACR AUC analysis due to premature removal from study because of disease progression. n = 11 mice in both groups. Percent reduction in UACR AUC with compound 3 treatment was calculated. UACR AUC data were log-transformed and analyzed by unpaired t-test. Significance was set at p ≤ 0.05. ****p < 0.0001. p < 0.0001 for Vehicle vs. treatment group. Results are presented as arithmetic mean ± SEM with each symbol representing an individual mouse. Representative data of n = 2 experiments. Source data are provided as a Source Data file.