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Experimental estimation of fundamental interaction constants for compounds A, B, and C. The SE associated with each fitted parameter is specified in brackets (value ± SE) and the goodness of fit for all fits was χ2 < 0.01 RU2. %Cc = 100(kinact)/(kinact + koff). *FP_kinact/KI was obtained from a fluorescent polarization biochemical assay (Supplemental Method S6) and *Cell_EC50 was obtained from a cell activity assay (Supplemental Method S5).
