Table 3.

Epitope scores for exons 8 and 9 in patients with mutations in these exons who did or did not develop IMM.

Mutation	Deletion exons 3–43	Deletion exons 8–9	Intron 7–exon 8 (40 bp)	Single nucleotide deletion, exon 9 (c.907del)	Deletion exons 8–9	Deletion exons 8–12
IMM	Yes	Yes	No	No	No	No
Exon 8	66.7	60.4	25.4 (31.9)*	0	77.6	50.2
Exon 9	20.0	41.6	0 (10.6)*	18.3	19.3	16.9

*For each patient, only the epitopes in the dystrophin protein sequence that cannot be naturally expressed due to his particular mutation were considered. In the patient with a splice site deletion between intron 7 and exon 8, the alternative translation start site present in exon 8 may or may not be used; the numbers in parentheses correspond to the latter situation.