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Average performance of leave-sgRNA-out test on pooled dataset (CHANGE-Seq + DeepCRISPR) against separate DeepCRISPR dataset. (A) PR curve for the global performance of CripsrBERT and BiLSTM models trained on pooled datasets and trained on DeepCRISPR-Seq dataset only. (B) ROC curve for the DL models as in (A). (C) Box-plot for the PR-AUC scores on each sgRNA for the same models as in (A). (D) Box-plot for the ROC-AUC scores on each sgRNA for the same models as in (A).
