Table 3.

RB with and without Extraocular Tumor Extension: Outcomes

Feature	RB with Extraocular Tumor Extension n = 319 n (%)	RB without Extraocular Tumor Extension n = 3116 n (%)	Odds Ratio (95% CI)	P Value
Duration of follow-up (mos), mean (median, range)	16 (11, <1–48)	30 (36, <1–51)	NA	0.0001
Systemic metastasis	67 (32)∗	105 (4)†	13.488 (9.645–18.862)	0.0001
Time interval between presentation and systemic metastasis (mos), mean (median, range)	5 (4, <1–22)	16 (12, <1–41)	NA	0.0001
Death due to RB	140 (63)‡	164 (6)§	33.004 (23.731–45.889)	0.0001
Time interval between presentation and death (mos), mean (median, range)	11 (9, <1–35)	17 (15, <1–43)	NA	0.0001

CI = confidence interval; NA = not applicable; RB = retinoblastoma.

^∗Outcomes were unknown in 107 patients.

^†Outcomes were unknown in 593 patients.

^‡Outcomes were unknown in 97 patients.

^§Outcomes were unknown in 451 patients.