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. 2025 Jan 2;44:1. doi: 10.1186/s13046-024-03250-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Integrin αvβ8 expression in KIRC and HNSCC as revealed by scRNA-seq analysis. (A) Ten freshly collected primary KIRC tissues were subjected to scRNA-seq analysis. (B) UMAP lots of KIRC patient cells, colored to depict the 12 identified clusters. (C) Distribution of ITGB8-expressing cells within each cluster of KIRC. (D) Point plot illustrating the distribution of ITGB8-expressing cells across various immune cell types in KIRC. (E) Analysis of 52 HNSCC tumor samples from individual patients as referenced in the literature. (F) UMAP plots of HNSCC patient cells, colored to show the 9 identified clusters. (G) Distribution of ITGB8-expressing cells within each cluster of HNSCC. (H) Point plot illustrating the distribution of ITGB8-expressing cells across various types of immune cells of HNSCC