Table 4.
Maternal and Cord RSV Anti-preF, IAV Anti-H3, and IAV Anti-H1 Protein Results in the General Cohort and by PTB and FTB Status
| Median (IQR) | ||||
|---|---|---|---|---|
| Total (N = 115) | <37 wk (n = 29) | ≥37 wk (n = 86) | P Value | |
| Anti-preF IgGa | ||||
| Maternal | 87 052 (46 999–144 508) | 87 052 (46 999–145 311) | 88 703 (51 379–136 642) | .84 |
| Cord | 135 652 (86 280–207 152) | 112 113 (60 468–139 984) | 146 182 (93 478–215 557) | .01 |
| Ratio | 1.64 (1.17–2.02) | 1.14 (0.98–1.57) | 1.75 (1.37–2.09) | .03 |
| Anti-H3 IgGb | ||||
| Maternal | 28 565 (14 144–53 089) | 24 284 (11 019–55 226) | 29 472 (14 144–51 345) | .73 |
| Cord | 43 361 (19 534–74 230) | 26 534 (13 977–49 613) | 49 094 (24 237–82 604) | .01 |
| Ratio | 1.50 (1.18–1.93) | 1.19 (0.88–1.41) | 1.61 (1.35–1.95) | .001 |
| Anti-H1 IgGc | ||||
| Maternal | 37 134 (18 782–103 467) | 34 265 (14 133–100 847) | 37 496 (19 271–103 467) | .81 |
| Cord | 56 545 (26 937–156 580) | 39 164 (26 581–86 775) | 59 625 (31 913–161 903) | .08 |
| Ratio | 1.49 (1.08–1.80) | 1.08 (0.81–1.49) | 1.64 (1.18–1.96) | .09 |
Statistical differences between vaccinated and unvaccinated mothers were assessed for maternal and cord anti-spike IgG by Wilcoxon rank sum test. Ratio is calculated as cord IgG divided by maternal IgG, and statistical differences between vaccinated and unvaccinated mothers were assessed by t test.
Abbreviations: FTB, full-term birth; IAV, influenza A virus; IgG, immunoglobulin G; PTB, preterm birth; preF, prefusion F; RSV, respiratory syncytial virus.
aMaternal and cord RSV anti-preF IgG results in the entire cohort and by PTB and FTB status.
bMaternal and cord IAV A/Hong Kong/4801/2014 anti-H3 IgG results in the entire cohort and by PTB and FTB status.
cMaternal and cord IAV A/Michigan/45/2015 anti-H1 IgG results in the entire cohort and by PTB and FTB status.