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. 2024 Dec 2;44(1):166–199. doi: 10.1038/s44318-024-00316-w

Figure EV5. High PF74 dosage leads to the disassembly of CPSF6 condensates, related to Figs. 6, 7 and 8.

Figure EV5

Immunostaining of cells kept in the same culture conditions as in Fig. 6A and an additional condition with lower PF74 dosage (1.25 µM) (blue = Hoechst; green = GFP; red = CPSF6; scale bar = 20 µm) (top panel). Graph showing the quantification of CPSF6 clusters per cell in cells treated with PF74 (1.25 and 25 µM) or not (Data are shown as the mean ± SD of two datasets of biological replicates, statistical test: ordinary one-way ANOVA; ∗∗∗∗: p-value= 6 × 10−14; ns: p-value = 0.6040) (bottom panel).