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. 2024 Dec 2;44(1):7. doi: 10.1038/s44318-024-00316-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A) ISGs induced after PF74 treatment. Twenty-four hours after treatment with PF74, or without any treatment, HIV-1 infected THP-1 cells (MOI 10) were analyzed for the expression of interferon-stimulated genes (ISGs) by RT-PCR: MxA, CXCL10, and IFIT-2. Fold increase RT-PCR data on amplicons derived from infected cells treated with PF74 in comparison to infected untreated cells are displayed. Statistical analysis was performed using one-way ANOVA test; MxA * indicates a p-value = 0.0163; CXCL10 *p value = 0.0354; IFIT2 *p value = 0.0152. Data derive from two independent experiments with four replicates for each and shown as the mean ± SD. (B) MDMs were infected with MOI 30 and treated or not with high dose of PF74. The cellular RNA extracted was used as template to amplify ISGs by RT-PCR: MxA, CXCL10, and IFIT-2. Fold increase RT-PCR data on amplicons derived from infected cells treated with PF74 in comparison to infected untreated cells from 6 healthy donors. Statistical analysis was performed using a one-way ANOVA test, data are shown as the mean ± SD of three replicates from each donor. MxA *** indicates a p-value = 0.000944, CXCL10 *** indicates a p-value = 0.000969 and IFIT2 ** indicates a p-value = 0.00478. Source data are available online for this figure.