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. 2025 Jan 2;16:318. doi: 10.1038/s41467-024-55467-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — a Structure of the 9C2 TCR ECD (Fab 2 complex used, Fab models hidden for clarity) with each TCRγ protomer colored a different shade of blue. Analysis of the TCRVγ5-mediated dimer interface with interacting residues shown as sticks and dashed lines representing putative hydrogen bonds. Note: TCRγ Y72 of protomer 1 forms a π-π interaction with Y72 of protomer 2. b Sequence alignment of various germline encoded TCR γ-chain variable regions. Residues that have been identified in the dimerization interface are labeled. CDRs are indicated with a faint yellow tint.