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Relationships between CD4+T-cell and B-cell responses to CD40.CoV2 vaccination. (a) Percent of spike-IgG+ human B cells in HIS-mouse spleens. Data were analyzed using the Mann–Whitney test. Median and individual values from two independent experiments are shown. ∗∗p < 0.01, ∗∗∗p < 0.001. (b) Correlation between the percentage of vRBD-specific cytokines+ (Th1) CD4+ T cells and the percentage of spike-IgG+ B cells. Statistical comparisons were performed using Spearman's correlation.
