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. 2024 Dec 11;111:105479. doi: 10.1016/j.ebiom.2024.105479

Fig. 4.

Fig. 4

The CD40.CoV2 vaccine induces stem-cell memory T cells. (a) Examples of FACS plots of memory T-cell staining performed on HIS-mouse spleens, gated on human CD45+ cells. The negative control for the hCD95 and hCD45RA staining was obtained by gating on mouse CD45+ cells. (b) Percentage of CM and (c) Tscm cells among human CD4+ T cells. (d) Percentage of CM and (e) Tscm cells among human CD8+ T cells. Data were analyzed using the Mann–Whitney test. Median and individual values from two independent experiments are shown. ∗p < 0.05, ∗∗p < 0.01. (f) Examples of FACS plots of memory T-cell staining performed on HIS-mouse spleens, gated on human HLA-A∗0201-RBD multimer CD8+ T cells. (g) Proportion of CD8+ T-cell memory subsets among the human HLA-A∗0201-RBD multimer CD8+ T cells elicited by the CD40.CoV2 vaccine injected with (pink triangles) or without poly-ICLC (blue squares). (h) Percentage of HLA-A∗0201-RBD multimer CD8+ Tscm cells in HIS-mouse spleens. Data were analyzed using the Mann–Whitney test. Median and individual values from two independent experiments are shown. ∗∗p < 0.01, ∗∗∗p < 0.001.