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. Author manuscript; available in PMC: 2025 May 1.
Published in final edited form as: Nature. 2024 Oct 23;635(8038):434–443. doi: 10.1038/s41586-024-08085-6

CRISPR guide RNAs to generate Il1b enhancer KO clones

gRNA name Location in the peak Guide RNAs
Il1b Peak 1 up Upstream CTCACCCAAAATTCACGTGTTGG
Il1b Peak 1 ds Downstream ATTGTCCTTGATTAGCTGACTGG
Il1b Peak 2 up Upstream CATGGCGGCTGCGACAGTTGGGG
Il1b Peak 2 ds Downstream ATTACGGGACTATGCGTCTGTGG
Il1b Peak 3 up Upstream TCCGTCTAGAGTTTCCCCTCTGG
Il1b Peak 3 ds Downstream CCCAGGAGTTCTACTAGCCTAGGG
Il1b Peak 4 up Upstream GACTTTTCGAGATTATGTAATGG
Il1b Peak 4 ds Downstream CCTGTGACAAGCAATCCCTCGGG
Il1b Peak 5 up Upstream CCCAGACAACCACTCCTCTCAGG
Il1b Peak 5 ds Downstream GACATCTCATTCCTCCAAGATGG
Il1b Peak 6 up Upstream CATCAACCAGGATTGGACGTGGG
Il1b Peak 6 ds Downstream TGAAATTAACAACGTCCTAGAGG
Il1b Peak 7 up Upstream ACTGGGCTAGTCCATCTGATTGG
Il1b Peak 7 ds Downstream ACAACTCAAGGGTCCCCATAGGG