FIG. 1.

Schematic representation of experimental paradigms. In Experiment 1 (top panel), adult male rats were trained in the 3-choice serial reaction time (3-CSRT) test, and upon meeting criterion performance was randomly assigned to either a controlled cortical impact (CCI) or sham surgery. Galantamine (GAL; 0.5, 2.0, or 5.0 mg/kg) or vehicle (VEH; 1 mL/kg) was administered starting 24-h after CCI or Sham surgery and continued once daily for 27 days. On behavioral days, GAL or VEH was administered 30 min before behavior onset. Three weeks after surgery, rats were tested on the 3-CSRT for 5 days. In Experiment 2 (bottom panel), age-matched rats were given a CCI surgery, administered the same doses of GAL or VEH as in Experiment 1, but from days 1–22 and 14 days later a guide cannula was surgically implanted in the medial prefrontal cortex (mPFC). One week after the guide cannula insertion (i.e., 3 weeks post-injury), a microdialysis probe was inserted into the mPFC and baseline and post-injection dialysate was collected.