FIG. 2.

Mean (±SEM) % accuracy (A) and % omissions (B) averaged for the last three baselines at the 2 s cue and then each day of 3-CSRT testing post-surgery. Repeated measures ANOVA revealed no statistical differences among the sham groups (n = 3–5/group), and therefore, they were pooled and designated as SHAMs (n = 18). (A) Three weeks following injury, rats displayed significant and persistent impairments in % accuracy, a measure of sustained attention. Student–Newman–Keuls post hoc tests revealed that the low (0.5 mg/kg) and moderate (2.0 mg/kg) galantamine (GAL) doses did not attenuate traumatic brain injury (TBI)-induced attentional deficits relative to vehicle (VEH) and that the higher dose (5.0 mg/kg) exacerbated impairments. (B) Assessment of % omissions, a measure of distractibility, indicated that GAL (0.5, 2.0, and 5.0 mg/kg) did not restore TBI-induced deficits. ^#p < 0.05 for SHAM vs. TBI + VEH and TBI + GAL (0.5, 2.0, and 5.0 mg/kg). *p < 0.05 for TBI + GAL (5.0 mg/kg) vs. TBI + VEH and TBI + GAL (0.5 and 2.0 mg/kg). n = 10–18/group.